Yes. All clients begin with a clinical assessment from Nul’s in-house team. This helps us make sure the programme is safe and effective for you, and may include a review of your medical history and relevant tests where necessary.

Yes. Nul’s programmes embrace the power of choice. Not everyone wants to quit entirely, and abstinence is not a requirement for participation in the programme. You’ll take your medication 1–2 hours before drinking, which, over time, helps reduce cravings and the compulsion to drink.

Naltrexone is an opioid antagonist that blocks the endorphin response alcohol typically produces in the brain. This reduces the rewarding effects of drinking, helping you break free from habitual patterns over time. As the brain stops associating alcohol with pleasure or relief, the urge to drink weakens. This is the foundation of the Sinclair Method**, which underpins Nul’s treatment programmes. Some people will be prescribed Nalmefene, that behaves in a similar way to Naltrexone.

If you forget to take your medication before drinking, take it as soon as you remember, then wait at least one hour before consuming alcohol. If you’re not drinking that day, no medication is required.

Many people report that alcohol feels less satisfying while on naltrexone. This is a sign that the extinction effect is working; the reward loop that was so entrenched in your neural pathways is slowly breaking down.

Nul’s therapists are trained in Internal Family Systems (IFS), a compassionate and evidence-based method that helps people identify the inner parts of themselves that drive behaviours like drinking. Instead of pathologising these parts, IFS helps you understand and integrate them, leading to deeper self-awareness, emotional healing, and sustainable change.

Not at all. There’s no 12-step structure, no labels, and no forced abstinence. Our therapy is trauma-informed, non-judgemental, and tailored to your unique relationship with alcohol and emotional history.

Sessions are conducted remotely with your dedicated therapist and/or as part of a group, and typically take place weekly. You’ll also have access to self-guided therapeutic content and tools between sessions to reinforce the ground you cover in your sessions.

The effect on physical cravings is noticeable almost immediately after taking Nul, but the emotional and psychological shifts take longer. Some people begin noticing changes within weeks, while others may take several months. Like when trying to make any big life changes, consistency and patience are key.

The Sinclair Method (TSM) is a medically supported treatment for alcohol reduction that uses naltrexone to change how your brain responds to alcohol. Developed by Dr. John Sinclair, the method is based on the principle of pharmacological extinction - the idea that, by consistently blocking the endorphin-driven rewards of drinking, the brain gradually loses interest in alcohol.

This approach allows you to continue drinking while the medication works to reduce cravings over time. Unlike abstinence-based models, TSM supports gradual behavioural change without requiring you to stop drinking immediately.

The method has been validated in over 90 peer-reviewed clinical trials, with success rates as high as 78% in reducing alcohol use long-term (Sinclair, 2001).