Minimal structure, maximum clarity. This programme combines discreet medicinal treatment with clinician check-ins, for a quiet, focused path forward.
Prescription medication delivered monthly (subject to clinical review and suitability)
Programme based on targeted Naltrexone or Nalmefene, according to The Sinclair Method (TSM)
Weekly coach-led support sessions
Thriva at-home liver function tests
High-touch clinician support whenever you need guidance
Monthly check-ins to measure progress
Duration – 3 months or more
Initial Consultation Required:
Before you commit, a liver function test and one-off £50 suitability assessment will help a clinician determine whether treatment is suitable for you.
This is a discreet and structured programme for reducing your alcohol consumption that combines non-addictive, clinically-proven medication taken before drinking, paired with monthly check-ins to back meaningful change with minimal friction.
Over the course of three months or more, you’ll steadily build new habits at your own pace, all while supported by our expert guidance. This is the quiet reset. No pressure, no noise, just the opportunity to drink less and grow more.
You can reach out to Nul anytime at hello@choosenul.com for clarifications or if you would like further advice. Don’t forget that during your programme, you will have access to check-ins with a registered clinician once a month to discuss how your treatment is going. And if needed, you will be able to reach a clinician for support at any time outside of these check-ins by getting in touch.
Not necessarily. You'll complete an online assessment and meet with a registered clinician trained in alcohol reduction by our partners at Blueco Healthcare, who will review your medical history and liver function tests. The clinician will be able to review your medical record and contact your GP if they need more information.
Yes. Not everyone wants to quit entirely, and abstinence is not a requirement for participation in the programme. You’ll take your medication 1–2 hours before drinking, which, over time, helps reduce cravings and the compulsion to drink.
The medication prescribed is either Naltrexone or Nalmefene. They are both opioid antagonists that block the endorphin response alcohol typically produces in the brain. This reduces the rewarding effects of drinking, helping you break free from habitual patterns over time. As the brain stops associating alcohol with pleasure or relief, the urge to drink weakens. This is the foundation of the Sinclair Method®, which underpins Nul’s treatment programmes.
¹Sinclair, John – Clinical Studies, 2001
Before drinking? Take it as soon as you remember and wait at least 1-2 hours as directed before drinking.
After drinking has started? Take it as soon as possible, but note that the extinction effect may be weaker.
Try to never skip your dose entirely.
Many people report that alcohol feels less satisfying while on Naltrexone. This is a sign that the extinction effect is working – the reward loop that was so entrenched in your neural pathways is slowly breaking down.
The effect on physical cravings is noticeable almost immediately after taking Nul, but the emotional and psychological shifts take longer. Some people begin noticing changes within weeks, while others may take several months. Like when trying to make any big life changes, consistency and patience are key.
Yes. The Nul Medication Programme is based on The Sinclair Method®, which is backed by over 90 clinical trials and has a 78% success rate in reducing alcohol use. It has been studied for decades and is widely recognised as an evidence-based approach to alcohol reduction.
¹Sinclair, John – Clinical Studies, 2001
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Registration No: 16119526. All rights reserved.
Healthcare Provider:
Blueco Healthcare Limited. Registration: Care Quality Commission (CQC), ID: 1-19176166626.
Registered Pharmacy:
Pharmalogic, 464 Ranglet Road, PR5 8AR GPhC Reg No: 9010938.
Superintendant Pharmacist:
Haroon Amanji. GPhC Reg No: 2070534.
